Glutathione: Benefits and Supplements Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Glutathione is known as the master antioxidant. This critical compound protects cells from damage caused by free radicals and toxins, supports detoxification, plays a key role in DNA synthesis and repair, Glutathione or GSH is an antioxidant in plants, animals, fungi, and some bacteria and archaea. 3d illustration Stock Photo Alamy The Controversial Role of Glucose6Phosphate Dehydrogenase Deficiency on Cardiovascular Disease: A Narrative Review Dore 2021 Oxidative Medicine and Cellular Longevity Wiley Online Library