Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Exploring the science behind Dihexa., Preclinical research examines its interaction with the HGF c Met pathway and associated neuroplasticity markers in laboratory and animal models. Human data PG 001HGF Alternative Peptide (c Met Agonist) PeptiGrowth Inc. Activated HGF c Met Axis in Head and Neck Cancer Structural basis of the activation of c MET receptor Nature Communications Hepatocyte Growth Factor MET Activator Rescues Working Memory Deficits after Repeated Mild Traumatic Brain Injury Katelyn A. Martino, Arush Nakhre, Renee M. Demarest, David M. Devilbiss, 2025