While it's been known that the essential function of #selenium was its incorporation as #selenocysteine into #selenoproteins (e.g. the enzyme #glutathioneperoxidase) now, Ingold et al. reveal the precise role of #selenolatebased #catalysis Selenoglutathione Diselenide: Unique Redox Reactions in the GPx Like Catalytic Cycle and Repairing of Disulfide Bonds in Scrambled Protein Biochemistry Catalytic cycle of (A) selenium dependent Gpx (SecGpx) and (B) Download Scientific Diagram The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities Selenium dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues ScienceDirect Mercury induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium glutathione axis BioMetals Springer Nature Link