Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports Tylenol's Impact on Glutathione and Liver Damage Glutathione detoxes tylenol and environmental toxins Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol depletes glutathione levels Is Tylenol Bad? 5 Dangers for Children & Adults Done With Diligence