Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update Comment below Dental Update Malignant oral melanoma: how to spot it and how it is managed Dental Update Oral Mucosal Melanosis IntechOpen Frontiers Mucosal Melanoma: Pathological Evolution, Pathway Dependency and Targeted Therapy Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.