Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Acetaminophen Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review How to Increase Glutathione Naturally: NAC, Glycine, and 7 Proven Methods Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen metabolism The Super Antioxidants: Glutathione And NAC! OC Integrative Medicine