Glutathione You Are The Healer How Acetaminophen Causes Liver Failure Biocompare: The Buyer's Guide for Life Scientists Don't Suppress a Fever Glutathione, Tylenol, and Vaccines: What Parents Need to Know Lotus Homeopathy, Inc. Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.