Oral Melanotic Macule: Symptoms and Treatment Skinsight Oral melanotic macule and primary oral malignant melanoma: Epidemiology, location involved, and clinical implications Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics Pigmented Lesions Pocket Dentistry Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Oral mucosal melanoma: epidemiology and pathobiology ScienceDirect A Case Report of Oral Malignant Melanoma: A Silent Killer Cureus