Tylenol's Impact on Glutathione and Liver Damage Tylenol's Impact on Glutathione and Liver Damage Tylenol depletes glutathione levels Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione, Tylenol, and Vaccines: What Parents Need to Know Lotus Homeopathy, Inc. Does Tylenol Cause Autism? Where the Idea Came From Wholehealthweb