Oral Melanosis Melanotan II Erectile Dysfunction Studies: What Early Research Shows and Practical Realities Orale melanosis 05 May 03 Eng Melanotan II Erectile Dysfunction: What You Need to Know Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.