Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation sagesteele @P_McCulloughMD While I dont know whether there is a connection between Tylenol and autism, I do believe that there is reason to STOP giving it to babies children. Glutathione is impacted by Tylenol and Glutathione: A Closer Look At Their Relationship Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine