Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: They told us Tylenol is safe. Pediatricians recommend them daily. But what if we've been missing the full story? Research shows that frequent use of acetaminophen (Tylenol) in babies and children