Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect The Key Health Benefits of S Acetyl Glutathione Water for Health AAAAI Mast Cell Disorders Committee Work Group Report: Mast cell activation syndrome (MCAS) diagnosis and management Journal of Allergy and Clinical Immunology Glutathione Pro Liposomal, 200 mg MCS Formulas S Acetyl Glutathione Active Form of Glutathione for Immune Health