Methylation cycle hypothesis MEpedia Methylation Profile Test Integrated Wellness Clinic Psychologists & Naturopaths Sunshine Coast, Brisbane & Gold Coast Under high oxidative stress, the body prioritizes glutathione production over methylation. Protect cells, DNA, and lipids first before building and detoxifying. #KalishInstitute #FunctionalMedicine Do you suffer with fatigue, brain fog, mood swings, or trouble detoxing? These could be signs of an MTHFR gene mutation, which affects methylationa key process for energy, detoxification, brain function, and HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution: Cell Reports Alterations in Histone H4 Lysine 20 Methylation: Implications for Cancer Detection and Prevention Semantic Scholar