Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Does anyone know what this black mark on my lip is? Started last August so it's I've had it nearly a year, was living in Spain at the time for 6 months Freckle mole on lips? : r HealthAnxiety Tiny brown spot on the lip? Don't ignore it. A melanotic macule is a small, well circumscribed brown to black oral lesion most commonly seen on the lower lip and a high yield ADC exam favourite. Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Melanotic Macules, Naevi, and Melanoma Springer Nature Link