The distance between a compound demonstrating efficacy in preclinical research and that compound appearing in a physician's standard toolkit can span a generation. The mechanisms by which NAC addresses oxidative stress, glutamate Plasma glutathione suggests oxidative stress is equally present in early and lateonset bipolar disorder Singh 2019 Bipolar Disorders Wiley Online Library Reduced Glutathione Capsules Exploring the Evidence of N Acetyl Cysteine (NAC) for Mood Disorders Psychopharmacology Institute Microbiotagutbrain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities Molecular Psychiatry Do You Have a Glutathione Deficiency?